Motho CYP2C19 Gene Polymorphism

CYP2C19 ke e 'ngoe ea li-enzyme tsa bohlokoa tse hlahisang li-enzyme lelapeng la CYP450.Li-substrates tse ngata tsa endogenous le hoo e ka bang 2% ea litlhare tsa kliniki li sebelisoa ke CYP2C19, joalo ka metabolism ea antiplatelet aggregation inhibitors (joalo ka clopidogrel), proton pump inhibitors (omeprazole), anticonvulsants, joalo-joalo. lithethefatsi tse amanang.Liphetoho tsena tsa lintlha tsa *2 (rs4244285) le *3 (rs4986893) li baka tahlehelo ea ts'ebetso ea enzyme e kentsoeng ke lefutso la CYP2C19 le bofokoli ba bokhoni ba metabolic substrate, le ho eketsa khatello ea mali, e le ho baka litlamorao tse mpe tsa lithethefatsi tse amanang le khatello ea mali.*17 (rs12248560) e ka eketsa ts'ebetso ea enzyme e kentsoeng ke CYP2C19 gene, tlhahiso ea metabolites e sebetsang, le ho ntlafatsa thibelo ea ho bokellana ha platelet le ho eketsa kotsi ea ho tsoa mali.Bakeng sa batho ba nang le metabolism e liehang ea lithethefatsi, ho noa litekanyetso tse tloaelehileng ka nako e telele ho tla baka chefo e tebileng le litla-morao: haholo-holo tšenyo ea sebete, tšenyo ea tsamaiso ea hematopoietic, tšenyo ea tsamaiso ea methapo ea bohareng, joalo-joalo, e ka lebisang lefung maemong a boima.Ho ea ka liphapang tsa motho ka mong ho metabolism e tsamaellanang le lithethefatsi, ka kakaretso e arotsoe ka li-phenotypes tse 'ne, e leng ultra-fast metabolism (UM,*17/*17,*1/*17), metabolism e potlakileng (RM,*1/*1) ), metabolism e bohareng (IM, *1/*2, *1/*3), metabolism e liehang (PM, *2/*2, *2/*3, *3/*3).